require_once(）: 需要打开失败

警告：require_once(C：/wamp/www/saleshub/system/startup.php(：失败打开流：没有这样的文件或目录C：''xampp''htdocs''saleshub''index.php 在第 17 行

致命错误：require_once((：需要打开失败"C：/wamp/www/saleshub/system/startup.php"(include_path='.;C：''xampp''php''PEAR'( inC：''xampp''htdocs''saleshub''index.php 在第 17 行

索引.php

<?php
// Version
define('VERSION', '2.0.2.0');
// Configuration
if (is_file('config.php')) {
    require_once('config.php');
}
// Install
if (!defined('DIR_APPLICATION')) {
    header('Location: install/index.php');
    exit;
}
// Startup
require_once(DIR_SYSTEM . 'startup.php');
// Registry
$registry = new Registry();
// Loader
$loader = new Loader($registry);
$registry->set('load', $loader);

startup.php coding 
<?php
// Error Reporting
error_reporting(E_ALL);
// Check Version
if (version_compare(phpversion(), '5.3.0', '<') == true) {
    exit('PHP5.3+ Required');
}
if (!ini_get('date.timezone')) {
    date_default_timezone_set('UTC');
}
// Windows IIS Compatibility
if (!isset($_SERVER['DOCUMENT_ROOT'])) {
    if (isset($_SERVER['SCRIPT_FILENAME'])) {
        $_SERVER['DOCUMENT_ROOT'] = str_replace('''', '/', substr($_SERVER['SCRIPT_FILENAME'], 0, 0 - strlen($_SERVER['PHP_SELF'])));
    }
}